Endocrine Abstracts

Introduction and Objectives: Pheochromocytomas and paragangliomas are rare neuroendocrine tumors derived from enterochromaffin tissue, mostly catecholamine-producing, adrenal gland (PCC) or extra-adrenal paraganglia (PGL). We were struck by the high incidence of these in our health care area, so we decided to study them. The aim of this work is to evaluate the clinical characteristics and epidemiological factors of patients diagnosed with PCC or PGL.Mate...

Introduction: Even Though resection via transsphenoidal surgery is the optimal primary treatment for growth hormone (GH) secreting pituitary adenomas, medical therapy must also be considered when biochemical control after surgery is not achieved. The aim of our study was to describe the cure rates of acromegaly patients after different lines of therapy.Methods: A retrospective study (1971–2022) of 89 patients diagnosed with acromegaly was conducted....

Background: Thyroid nodules are one of the most common clinical entities in Endocrinology practice. Fine needle aspiration (FNA) and the 2017 Bethesda System for Reporting Thyroid Cytopathology have been proved to be an effective tool to identify malignancy risk and guide surgical decision-making. However, thyroid nodules classified as Bethesda (BTH) III and IV remain a challenge, considering the varying risk of malignancy (ROM) found in different papers. The aim of this study...

Evidence on whether neonatal thyroid screening results are dependent on maternal thyroid function is limited.Objectives: To study the relationship between iodine status and maternal thyroid function in pregnancy, and neonatal screening results in a Northern Spanish population.Methods: Prospective, longitudinal study of 297 pregnant women recruited in 2 obstetric centers of Pamplona (Spain) at the first antenatal visit, and their ne...

Woman, 40 years old. Smoker and habitual drinker, history of toxic consumption, anxiety-depressive syndrome, postsurgical hypothyroidism after total thyroidectomy for multinodular goiter in substitution treatment. Diabetes mellitus type 1 diagnosed in 2001 as a result of pregnancy, unstable, with poor chronic glycemic control, requiring frequent admissions to our hospitalization plant due to episodes of ketoacidosis. It requires high insulin requirements and does not present m...

Introduction: Recent studies suggest that some patients initially diagnosed with congenital hypogonadotropic hypogonadism (CHH), may evolve towards a combined pituitary hormonal deficiency (CPHD). Heterozygous pathogenic CHD7 variants impair neural cell crest guidance causing CHARGE syndrome and have been associated with abnormal pituitary development/function/structure and isolated CHARGE features, including HH. We aimed to genotype CHD7 and phenotype thoroughly those adult p...

A 56-year-old Swedish male was diagnosed with hypertension, initially attributed to continued use of NSAIDs. These were withdrawn and treatment with 80 mg valsartan was started, but BP remained uncontrolled. A fixed combination (valsartan/hydrochlorothiazide, 80/12.5 mg) was introduced, but blood pressure remained high and hypokalemia (K+3.3 mEq/l) developed. The patient was referred to our Endocrinology Clinic for study. Treatment was switched to manidipine 10 mg/1...

Introduction and objectives: A possible increase in blood pressure (BP) and other cardiovascular risk factors has been associated with testosterone treatment (TT) in female-to-male transsexuals (FMT). Nonetheless, the available evidence does not support an increase in CV morbidity or mortality. We set out to analyze the impact of TT on BP and lipid profile in a cohort of FMT patients.Methodology: Retrospective observational study with no control group in...

Introduction: In addition to the medication prescribed by their doctors, patients may recourse to natural medicine and take herbal medications without thinking about their potential side effects and interactions with other drugs.Case Report: A 39-year-old female, with personal history of iron deficiency anemia, regular menses but long-standing dysmenorrhea and polymenorrhea and reactive anxiety-depressive disorder, complained of frequent intermenstrual s...

Gestational diabetes mellitus (GDM) is associated with an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to screen for PIH and preeclampsia in normotensive type 1 diabetic women. To date, there are no data regarding ABPM in women with GDM. The aim of the study was to establish blood pressure (BP) profiles for pregnant with GDM, using ABPM and determine whether a BP pattern can define a population at risk for de...